HOME   |   ABOUT   |   CONTACT

Psychiatric Genomics Research Stream

Psychiatric Genomics Research Stream

Schizophrenia is a complex disorder with a strong genetic component

Led by Professor Bryan Mowry, QCMHR’s Psychiatric Genomics Research Group is based at the Queensland Brain Institute. The Mowry Group‘s work is focused on identifying risk genes for schizophrenia, and profiling the roles of these genes using neuroimaging and animal models. A second focus is to serve the need to develop more effective medications for patients by using zebrafish to identify novel or repurposed drugs.

In addition to work conducted within the laboratory, the group has conducted large-scale, collaborative studies of genetically isolated populations in Chennai, India, and Sarawak, Malaysia. This work has involved recruiting and diagnosing thousands of individuals with schizophrenia and related disorders and conducting genetic analyses on DNA extracted from blood samples. This group has also contributed to large consortia at both the national (Australian Schizophrenia Research Bank) and international (Psychiatric Genomic Consortium) levels. These collaborations have resulted in huge strides in our understanding of the complex genetics behind this complex disorder.

The group’s work in identifying risk genes and understanding the role they play in schizophrenia development and progression will be vital in providing better-targeted therapies for this debilitating disorder in the future.

Research areas include:

  • Genome-wide Association Studies (GWAS)
  • DNA, RNA Sequencing
  • Gene Expression and editing
  • Neuroimmunology of schizophrenia
  • Zebrafish models and functional genetics
  • Microscopy
  • Drug discovery
  • Chemical genetics
  • Statistical genomics and computational biology
  • Applications of deep learning in biomedicine

 

Staff

Professor Bryan Mowry

HeadPsychiatric Genetics Research Stream Academic Title Holder - ProfessorQueensland Brain Institute



Dr Sathish Periyasamy

Academic Title - Research FellowQueensland Brain Institute



Heather Smith

Research OfficerPsychiatric Genomics Research Stream Adjunct Research FellowQueensland Brain Institute, The University of Queensland


External links
Queensland Brain Institute - Mowry Group
Queensland Brain Institute - Mowry Group

The primary research goal is to identify and functionally characterise susceptibility genes for schizophrenia and related disorders. A special focus is on the study of large collaborative samples and ethnically homogeneous populations.

The group aims to achieve this by using genome-wide association studies (GWAS), DNA and RNA sequencing, and gene expression studies.

VISIT WEBSITE
Contact us

Want to know more about QCMHR? Click the button to get in touch with us!

Image

HEAD OFFICE

Level 3, Dawson House
The Park Centre for Mental Health Treatment
Research and Education, Wacol, QLD 4076
P: +61 7 3271 8704

ACKNOWLEDGEMENT OF COUNTRY

In the spirit of reconciliation, the Queensland Centre for Mental Health Research (QCMHR) acknowledges the Traditional Owners of the lands in which QCMHR operates and their continuing connections to land, waters and community. We pay our respects to Elders past and present and stand together with all Aboriginal and Torres Strait Islander peoples.